SIOP PNET5 trial funding

We have partnered with The Brain Tumour Charity to co-fund a ground-breaking clinical trial aimed at improving treatments for children diagnosed with medulloblastoma, the type of tumour which took Oscar’s life in May 2014.

The SIOP PNET5 trial aims to find out if children with certain types of medulloblastoma can receive less toxic chemotherapy and a lower dose of radiotherapy without reducing their chance of survival.


How will my money help?

How will my money help?

In the first year of the trial we need to raise £250,000

  • £10 will pay for an antibody test to identify how the immune system is responding
  • £60 will pay for a genetic test to assess a particular gene that plays a role in cell growth, division and change, called the MYC gene
  • £350 will pay for a test called a DNA methylation array to assess the molecular subgroup of a tumour
  • £2,000 will pay for a full molecular diagnostic analysis on a single medulloblastoma tumour for one child


About Us

Oscar Hughes

OSCAR’s (Ongoing, Support, Care And Research into) Paediatric Brain Tumour Charity was formed in November 2014 by the parents and friends of Oscar Hughes, a 9 year old boy who died of a Medulloblastoma (a brain tumour) in May 2014.

Oscar was a sporty and energetic 8 year old when he was first diagnosed. His motto was “A day without training is a day without meaning”. As he went through treatment he put all his energy into staying strong for his siblings and friends, as well as fundraising for other children with cancer. In particularly he raised over £6K through a marathon relay in which he himself took part at a time when even walking was a challenge.

The journey Oscar went on for a year to try and be free of cancer was both heartbreaking and inspiring to see. The treatments involved to fight brain tumours have devastating effects on a young body and mind. This is unacceptable and the only way to change this is by researching these cancers and find better treatments.

The charity aims to fund critical research into paediatric brain tumours with the hope to find a cure and less devastating treatments and works closely with other charities.

Research Changes Lives

Where Your Money Goes

Tom Daley patron of The Brain Tumour Charity

Projects we fund

Brain tumours are the biggest cancer killers in people under the age of 40, a fact many people are unaware of.

The five-year survival rate for brain tumours is only 19.8% whereas for other cancers it is 50%. It is a misconception by the government and other organisations that brain tumour research doesn’t need much funding; this is due to the rarity of brain tumours. However when we lose more young people to brain tumours than to any other cancer, and when brain tumour patients are left with a poor quality of life, this is just not good enough.

But we can change this. Research changes lives.

OSCAR’s PBTC is part-funding the PNET5 clinical trial with The Brain Tumour Charity (TBTC) – this is a vital clinical trial studying improved treatments for children diagnosed with medulloblastoma. Medulloblastoma is the most common paediatric brain tumour but treatments are aggressive and can leave long-term, life-altering disabilities for children. It’s a terrible burden for children to bear for the rest of their lives. But, with PNET5, we’re on the verge of a major breakthrough for medulloblastoma treatment.

Read More

We have agreed to donate £125,000 over 5 years towards improving understanding and treatment of the type of childhood brain tumour which took Oscar’s life. Led by Professor Chesler, the team is working to study Group 3 medulloblastoma. They will be analysing the genome in medulloblastoma tumour cells while also working on new ways to test drugs for this tumour type.

Read More

Marie's Blog

Donate and help fund research


Everyone with OSCAR’s PBTC is an unpaid volunteer. We happily give our time & energy to organise & run events, to fundraise and in our own time and our own way, spread the word.

We do what we can because we want to make a difference: we don’t want any more kids to go through what Oscar went through. As a new charity we have pledged that as much money as possible from what we raise will go directly to paediatric brain tumour research.

It is our wish to help drive down diagnosis time, increase survival rate and quality of life after treatment.